Rodriguez Jornet A, Matías-Guiu J, Coll de Tuero G, Villegas Sánchez G, Sánchez Novials A, Sabriá Leal M
Med Clin (Barc). 1981 Oct 10;77(6):250-2.
The authors report a patient who developed a mononucleotic syndrome after 2 months treatment with diphenylhydantoin. The clinical and biological criteria needed to establish the diagnosis of pseudomononucleosis are listed, while other possible causes described in the literature have been excluded. Complications which may occur during anti-convulsant therapy with diphenylhydantoin are reviewed and the few cases of pseudomononucleosis in the literature noted. Diagnosis was established through eliminating other possible causes, as the only definite test-drug induced reaction-is hazardous to the patient.
作者报告了一名患者,该患者在接受苯妥英治疗2个月后出现单核细胞增多综合征。文中列出了诊断假性单核细胞增多症所需的临床和生物学标准,同时排除了文献中描述的其他可能病因。对苯妥英抗惊厥治疗期间可能出现的并发症进行了综述,并提及了文献中少数假性单核细胞增多症病例。由于唯一明确的检测——药物诱发反应——对患者有危害,因此通过排除其他可能病因来确立诊断。