Weedon A P
Aust N Z J Med. 1975 Dec;5(6):561-3. doi: 10.1111/j.1445-5994.1975.tb03863.x.
A ten-year-old boy presented with an illness resembling infectious mononucleosis associated with an unusual skin rash and marked cholestatic hepatitis. This combination represents a rare reaction to diphenylhydantoin. Few reported cases have been published. The illness commences from three to seven weeks after starting therapy. Although one death has been reported, other cases have shown complete recovery. Early recognition of the combination of symptoms and cessation of drug therapy is essential.
一名10岁男孩出现类似传染性单核细胞增多症的疾病,伴有不寻常的皮疹和明显的胆汁淤积性肝炎。这种情况代表了对苯妥英的罕见反应。已发表的报道病例很少。疾病在开始治疗后3至7周开始。虽然有一例死亡报告,但其他病例已完全康复。早期识别症状组合并停止药物治疗至关重要。