Kimura T, Share L, Wang B C, Crofton J T
Neuroendocrinology. 1981 Dec;33(6):347-51. doi: 10.1159/000123259.
In order to investigate the role of central dopaminergic receptors in the control of vasopressin release and in cardiovascular regulation, the effects of intracerebroventricular administration of dopamine (DA) and bromocriptine (BC), a specific DA agonist, were compared in the anesthetized dog. The drugs were infused over a 20-min period into a lateral ventricle. DA brought about a transient decrease in mean arterial blood pressure, a slight increase in heart rate toward the end of the experiment, and a suppression of vasopressin release. BC increased heart rate and decreased blood pressure to a greater extent than did DA, and doubled the plasma vasopressin concentration. The increase in vasopressin secretion preceded the fall in blood pressure, ans was, therefore, due to a direct central action of BC. Although in these circumstances it is difficult to determine the role of dopaminergic neurons in the control of vasopressin release, there is some reason to believe that this role may be expressed by the actions of BC under the present experimental conditions.
为了研究中枢多巴胺能受体在血管加压素释放控制及心血管调节中的作用，在麻醉犬中比较了脑室内注射多巴胺（DA）和特异性DA激动剂溴隐亭（BC）的效应。药物在20分钟内注入侧脑室。DA使平均动脉血压短暂下降，实验快结束时心率略有增加，并抑制血管加压素释放。BC比DA更显著地增加心率和降低血压，并使血浆血管加压素浓度加倍。血管加压素分泌增加先于血压下降，因此是BC直接中枢作用所致。尽管在这些情况下难以确定多巴胺能神经元在血管加压素释放控制中的作用，但有理由相信在当前实验条件下，这种作用可能通过BC的作用表现出来。
