Möhring J
Klin Wochenschr. 1978;56 Suppl 1:71-9. doi: 10.1007/BF01477456.
Studies on the vasopressor role of the antidiuretic hormone arginine-vasopressin (AVP) in DOC hypertension, in two-kidney Goldblatt hypertension, and in spontaneous hypertension of rats, and during acute blood pressure elevation after intracerebroventricular injection of angiotensin II and in glycerol-induced acute renal failure of rats are reviewed. For the measurement of plasma AVP a radioimmunoassay has been developed. For this assay, a series of criteria has been met which allows the conclusion that, in plasma of rats, the antibody measures AVP only. For the blockade of vasopressor effects of AVP a specific antiserum has been used. On the basis of a series of control studies it has been concluded, but not proven that the antiserum lowers blood pressure exclusively by blockade of AVP. It could be shown that in the various animal models of hypertension and of acute blood pressure elevation AVP exerts systemic vasoconstriction when its plasma concentrations are elevated. In those models where the renin-angiotensin system played no role in blood pressure control, the height of blood pressure was closely related to the plasma AVP concentrations. When this relationship was compared with that obtained after the i.v. infusion or injection of AVP, a marked shift to the left became apparent. Hence, sensitization to the vasopressor effect of AVP had occurred, the factor of sensitization amounting to more than 1,000. It is concluded that AVP is not only an antidiuretic hormone but also a vasopressor hormone, and that any systemic vasopressor effect of AVP requires a mechanism of sensitization.
本文综述了抗利尿激素精氨酸血管加压素（AVP）在去氧皮质酮高血压、双肾型Goldblatt高血压和大鼠自发性高血压中，以及在脑室内注射血管紧张素II后急性血压升高期间和甘油诱导的大鼠急性肾衰竭中的升压作用。已开发出一种放射免疫分析法用于测量血浆AVP。对于该分析，满足了一系列标准，由此可以得出结论，在大鼠血浆中，该抗体仅测量AVP。为阻断AVP的升压作用，使用了一种特异性抗血清。基于一系列对照研究得出结论，但未得到证实，即该抗血清仅通过阻断AVP来降低血压。可以表明，在各种高血压和急性血压升高的动物模型中，当血浆AVP浓度升高时，AVP会引起全身血管收缩。在那些肾素 - 血管紧张素系统在血压控制中不起作用的模型中，血压高度与血浆AVP浓度密切相关。当将这种关系与静脉输注或注射AVP后获得的关系进行比较时，明显向左发生了显著偏移。因此，已发生对AVP升压作用的致敏，致敏因子超过1000。得出的结论是，AVP不仅是一种抗利尿激素，也是一种升压激素，并且AVP的任何全身升压作用都需要一种致敏机制。
