Bulatov A A, Sadovnikova N V
Probl Endokrinol (Mosk). 1981;27(6):63-5.
The ability of somatotropin seival and its fragment 77-107, retaining a marked growth-stimulationg activity, to change the intensity of 14C-glucose consumption from the medium and 14C-glucose inclusion into glycogen by in vitro incubated semidiaphragm of hypophysectomized rats was studied. It was detected that somatotropin seival, contacting with the diaphragmatic muscle tissue, provokes "insulin-like" effect. (i.e. stimulates glucose consumption and glycogen synthesis by this tissue), similar to that of the other animal somatotropins studied. Somatotropin fragment 77-107, revealing growth-stimulating activity, is not able to intensify glucose consumption and glycogen synthesis in the muscle tissue, in contrast to the whole hormone, being indicative of dissociation between structural determinants of these effects in hormone molecule.
研究了生长激素西伐及其片段77 - 107在保留显著生长刺激活性的情况下，对垂体切除大鼠体外培养的半膈肌从培养基中摄取14C - 葡萄糖以及将14C - 葡萄糖纳入糖原的强度的影响。检测发现，生长激素西伐与膈肌肌肉组织接触时会引发“胰岛素样”效应（即刺激该组织摄取葡萄糖和合成糖原），这与所研究的其他动物生长激素类似。与完整激素相反，具有生长刺激活性的生长激素片段77 - 107无法增强肌肉组织中的葡萄糖摄取和糖原合成，这表明激素分子中这些效应的结构决定因素之间存在解离。
