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绵羊发情周期和妊娠早期催产素的循环浓度。

Circulating concentrations of oxytocin during the estrous cycle and early pregnancy in sheep.

作者信息

Sheldrick E L, Flint A P

出版信息

Prostaglandins. 1981 Oct;22(4):631-6. doi: 10.1016/0090-6980(81)90072-1.

DOI:10.1016/0090-6980(81)90072-1
PMID:7323312
Abstract

Plasma concentrations of oxytocin and progesterone have been measured by radioimmunoassay in jugular venous blood obtained daily from 5 sheep during 2 estrous cycles and in early pregnancy. Concentrations of oxytocin were relatively high (15-30) pg/ml) during the luteal phase of the cycle, but fell at estrus (to 1-17 pg/ml). A fall in oxytocin was also observed on day 15 of pregnancy, when, as expected, progesterone levels remained high. It is suggested that raised basal levels of oxytocin are unlikely to cause the increased uterine release of prostaglandin F2 alpha which occurs at the end of the estrous cycle.

摘要

在两个发情周期以及妊娠早期,每天从5只绵羊采集颈静脉血,通过放射免疫分析法测定其中催产素和孕酮的血浆浓度。在发情周期的黄体期,催产素浓度相对较高(15 - 30皮克/毫升),但在发情期下降(至1 - 17皮克/毫升)。在妊娠第15天也观察到催产素下降,此时孕酮水平如预期保持在高位。研究表明,基础催产素水平升高不太可能导致发情周期末期子宫前列腺素F2α释放增加。

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1
Circulating concentrations of oxytocin during the estrous cycle and early pregnancy in sheep.绵羊发情周期和妊娠早期催产素的循环浓度。
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Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers.测量催产素和加压素:生物测定法、免疫测定法与随机数
J Neuroendocrinol. 2016 Oct;28(10). doi: 10.1111/jne.12413.
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Morphine tolerance and inhibition of oxytocin secretion by kappa-opioids acting on the rat neurohypophysis.吗啡耐受性以及κ-阿片类物质作用于大鼠神经垂体对催产素分泌的抑制作用。
J Physiol. 1993 Sep;469:365-86. doi: 10.1113/jphysiol.1993.sp019818.
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Pulsatile secretion of oxytocin during parturition in the pig: temporal relationship with fetal expulsion.猪分娩过程中催产素的脉冲式分泌:与胎儿排出的时间关系。
J Physiol. 1994 Feb 15;475(1):129-37. doi: 10.1113/jphysiol.1994.sp020054.
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Naloxone excites oxytocin neurones in the supraoptic nucleus of lactating rats after chronic morphine treatment.慢性吗啡处理后,纳洛酮可兴奋哺乳期大鼠视上核中的催产素神经元。
J Physiol. 1988 Feb;396:297-317. doi: 10.1113/jphysiol.1988.sp016963.
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A review of some aspects of the pharmacology of oxytocin in domestic animals.家畜中催产素药理学某些方面的综述。
Vet Res Commun. 1991;15(1):45-55. doi: 10.1007/BF00497789.