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[撤用巴比妥类药物儿童的慢睡眠节律的地形分布(作者译)]

[Topographical distribution of slow sleep rhythms in children withdrawn from barbiturates (author's transl)].

作者信息

Findji F, Catani P

出版信息

Rev Electroencephalogr Neurophysiol Clin. 1981 Nov;11(2):218-27. doi: 10.1016/s0370-4475(81)80056-1.

Abstract

An automatic analysis of the topographical distribution of slow sleep rhythms was performed and 53 night sleep recordings obtained from 10 children chronically treated by barbiturates; a barbiturate withdrawal was undertaken in these children to eliminate the side effects of the drug likely to impair their development or their behaviour. Compared to the data obtained in a control group, marked differences were observed in this population, bearing on the magnitude, the topographical distribution and the interhemispheric symmetry of the delta power curves. During and after withdrawal, changes could occur in these curves; as a whole, the organization of the curves was closer to those of controls when the withdrawal was completed for at least 2 months but their magnitudes remained either higher or lower than control values. No relationship could be established between the curve parameters and the dosage of the drug. The observed changes between successive records are interpreted in relation to the concept of cerebral plasticity.

摘要

对慢睡眠节律的地形分布进行了自动分析,并从10名长期接受巴比妥类药物治疗的儿童中获取了53份夜间睡眠记录;对这些儿童进行了巴比妥类药物戒断,以消除可能损害其发育或行为的药物副作用。与对照组获得的数据相比,在这一人群中观察到了明显差异,涉及δ功率曲线的幅度、地形分布和半球间对称性。在戒断期间和之后,这些曲线可能会发生变化;总体而言,当戒断至少完成2个月时,曲线的组织更接近对照组,但它们的幅度仍高于或低于对照值。曲线参数与药物剂量之间无法建立关系。根据大脑可塑性的概念对连续记录之间观察到的变化进行了解释。

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