Alexander I E, Lumbers E R
Respir Physiol. 1981 Dec;46(3):261-70. doi: 10.1016/0034-5687(81)90126-2.
The effects of a pressor dose of angiotensin II on the respiratory pattern of chloralose anaesthetized mongrel dogs was studied. In addition, since the hypertensive action of angiotensin II stimulates baroreflex pathways, the effects on breathing of baroreceptor stimulation were examined using aortic balloon inflation and i.v. phenylephrine. In the baroreceptor-denervated dog, i.v. angiotensin II was associated with a reduction in both inspiratory and expiratory time while both inspiration and expiration proceeded more quickly. Thus breathing became deeper and more rapid. Most of these effects of angiotensin II were opposite to the effects of hypertension caused by phenylephrine and aortic balloon inflation. These two forms of hypertension caused an increase in inspiratory and expiratory time, a decrease in the rate at which inspiration proceeded and a fall in tidal volume. These effects were not seen in baroreceptor denervated animals. In the intact dog angiotensin II caused a marked vagal dependent fall in tidal volume and inspiratory time while the rates at which inspiration and expiration proceeded were unaffected. It is concluded that angiotensin II has three independent effects on respiration. These are a respiratory depressant effect due to stimulation of baroreflex pathways by its pressor action, a 'central' stimulatory effect and an effect on the vagal control of inspiratory time.
研究了升压剂量的血管紧张素II对水合氯醛麻醉的杂种犬呼吸模式的影响。此外，由于血管紧张素II的升压作用会刺激压力反射通路，因此使用主动脉球囊充气和静脉注射去氧肾上腺素来研究压力感受器刺激对呼吸的影响。在压力感受器去神经支配的犬中，静脉注射血管紧张素II会导致吸气和呼气时间缩短，同时吸气和呼气都进行得更快。因此，呼吸变得更深更快。血管紧张素II的这些作用大多与去氧肾上腺素和主动脉球囊充气引起的高血压的作用相反。这两种高血压形式导致吸气和呼气时间延长，吸气进行的速率降低，潮气量下降。在压力感受器去神经支配的动物中未观察到这些作用。在完整的犬中，血管紧张素II导致潮气量和吸气时间明显依赖迷走神经下降，而吸气和呼气进行的速率未受影响。得出的结论是，血管紧张素II对呼吸有三种独立的作用。这些作用包括由于其升压作用刺激压力反射通路而产生的呼吸抑制作用、“中枢”刺激作用以及对迷走神经控制吸气时间的作用。
