Zoli M, Marchesini G, Angiolini A, Dondi C, Bianchi F B, Pisi E
Scand J Gastroenterol. 1981;16(5):689-92. doi: 10.3109/00365528109182031.
To determine the role of liver dysfunction in the plasma amino acid profile of cirrhotic patients, we correlated basal plasma amino acids and several biochemical and functional hepatic variables in 29 cirrhotics with normal mental state or mild encephalopathy. Increased levels of aromatic amino acids and free tryptophan correlated positively with the extent of portosystemic shunt, as assessed by the ammonia tolerance test (r = 0.758 and r = 0.589, respectively). There was a negative correlation between these amino acids and liver function, as evaluated by the galactose elimination capacity test (r = -0.657 and r = -0.551), thus suggesting that phenylalanine, tyrosine, and free tryptophan may be considered indexes of liver dysfunction in non-comatose cirrhotics.
为了确定肝功能不全在肝硬化患者血浆氨基酸谱中的作用，我们将29例精神状态正常或有轻度肝性脑病的肝硬化患者的基础血浆氨基酸与几种肝脏生化和功能变量进行了相关性分析。芳香族氨基酸和游离色氨酸水平的升高与经氨耐受试验评估的门体分流程度呈正相关（分别为r = 0.758和r = 0.589）。通过半乳糖清除能力试验评估，这些氨基酸与肝功能呈负相关（r = -0.657和r = -0.551），因此表明苯丙氨酸、酪氨酸和游离色氨酸可被视为非昏迷肝硬化患者肝功能不全的指标。
