Elo J, Tallgren L G, Sarna S, Alfthan O, Stenström R
Scand J Urol Nephrol. 1981;15(3):243-8. doi: 10.3109/00365598109179611.
Observations are reported from a series of 284 children, 68 boys and 216 girls, who had had one or more episodes of urinary tract infection (UTI) and had vesicoureteral reflux (VUR) of grade II, III or VI. In 6 of the boys and 43 of the girls the Politano-Leadbetter operation for correction of VUR was performed. Only in grade III or IV VUR was the cure rate--considered solely as cessation of reflux--significantly higher in surgically than in non-surgically treated children. Irrespective of sex or mode of treatment, the number of episodes of UTI tended to diminish as the children grew older. For more precise comparisons, two individually matched groups of 40 girls were studied. One girl in each pair was operated on. Within these matched pairs, the frequency of UTI episodes according to age did not differ appreciably. Nor did the number of UTI episodes before and after the time of operation differ significantly when analysis was made according to grade of reflux. Thus, although disappearance of surgically treated grades III and IV VUR was more rapid and more frequent than spontaneous cessation of reflux, the observations in the matched pair series indicated that antireflux surgery does not affect the incidence of UTI.
报告了对284名儿童的观察结果，其中68名男孩和216名女孩曾有过一次或多次尿路感染（UTI），并患有II级、III级或VI级膀胱输尿管反流（VUR）。6名男孩和43名女孩接受了Politano-Leadbetter手术以纠正VUR。仅在III级或IV级VUR中，手术治疗儿童的治愈率（仅视为反流停止）显著高于非手术治疗儿童。无论性别或治疗方式如何，随着儿童年龄增长，UTI发作次数往往会减少。为了进行更精确的比较，对两组各40名女孩进行了个体匹配研究。每对中的一名女孩接受了手术。在这些匹配对中，根据年龄的UTI发作频率没有明显差异。根据反流等级进行分析时，手术前后的UTI发作次数也没有显著差异。因此，尽管手术治疗的III级和IV级VUR消失比反流自发停止更快、更频繁，但匹配对系列中的观察结果表明，抗反流手术不影响UTI的发生率。
