Guerra M F, Marsden P D, Cuba C C, Barretto A C
Trans R Soc Trop Med Hyg. 1981;75(3):335-7. doi: 10.1016/0035-9203(81)90086-9.
At a dosage level of 8 to 10 mg/kg body-weight daily for 120 days nifurtimox was associated with clinical healing of cutaneous leishmaniasis in five of eight patients. At a dosage level of 20 mg/kg body-weight daily for 10 days in six of 10 patients the skin ulcer healed. Results and the reasons why both schemes are impracticable are briefly discussed.
以每日8至10毫克/千克体重的剂量服用硝呋替莫120天,8名患者中有5名皮肤利什曼病实现临床治愈。以每日20毫克/千克体重的剂量服用硝呋替莫10天,10名患者中有6名的皮肤溃疡愈合。本文简要讨论了这两种方案不可行的结果及原因。