Lowe C A, Shaffer T H
Undersea Biomed Res. 1981 Dec;8(4):229-38.
The effect of liquid ventilation on pulmonary vascular resistance was studied in an isolated cat lung preparation in situ. Lungs were perfused with whole blood from a donor cat at a constant flow of 100 ml . min-1 kg-1. Pulmonary arterial venous pressures were measured, and pulmonary vascular resistance calculated during gas ventilation (control) and ventilation with fluorocarbon, FC-80. During control ventilation at a mean tidal volume (VT) of 28 +/- 1 (SEM) ml and lung volume of 108 +/- 8 (SEM) ml, pulmonary vascular resistance was 0.07 +/- 0.01 (SEM) PRU. During liquid ventilation at similar lung volumes, pulmonary vascular resistance increased by 62% to 0.12 +/- 0.03 (SEM) PRU (P less than 0.05). At greater liquid lung volumes reflecting optimum CO2 elimination, pulmonary vascular resistance increased by 115% over control values to 0.15 +/- 0.01 (SEM) PRU (P less than 0.005). These data demonstrate significant alterations in pulmonary circulation during liquid ventilation, and suggest that further studies should be completed before hyperbaric applications in human can be considered.
在原位分离的猫肺标本中研究了液体通气对肺血管阻力的影响。用供体猫的全血以100 ml·min⁻¹·kg⁻¹的恒定流量灌注肺。测量肺动脉和静脉压力，并计算气体通气（对照）和用氟碳化合物FC - 80通气期间的肺血管阻力。在平均潮气量（VT）为28±1（标准误）ml且肺容积为108±8（标准误）ml的对照通气期间，肺血管阻力为0.07±0.0
