Catabolism of desialylated glycoproteins during carcinogenesis and inflammation in rats.

Experiments were performed on rats injected with a malignant hepatoma (evoked by aflatoxin B1) or with inflammation induced by turpentine injection. On the 4th or 8th day after the injection, the following determinations were made: concentration of seromucoid, haptoglobin, sialic acid and fucose in blood serum; binding of asialo-glycoproteins by liver extracts; elimination of asialo-[125I]haptoglobin and asialo-[125I]orosomucoid from circulation. It was found that hepatoma and inflammation affected neither the activity of liver receptors for asialo-glycoproteins, nor the rate of asialo-glycoprotein elimination from circulation.