逼近与疾病传播多因素模型特别相关的三变量正态概率。

Approximating a trivariate normal probability that is of special relevance to the multifactorial model of disease transmission.

作者信息

Hutchinson T P

出版信息

Ann Hum Genet. 1980 Jul;44(1):107-11. doi: 10.1111/j.1469-1809.1980.tb00950.x.

DOI:10.1111/j.1469-1809.1980.tb00950.x

Abstract

A study has been made of methods of approximating the probability of severe disease occurrence in the child of parents who both suffer from a mild (or subclinical) form of the disease in question. A wide range of parameter values has been considered. It has been found that (i) The Mendell-Elston formula is very accurate. (ii) The simple pseudo-Pareto formula is not quite as accurate as the Mendell-Elston, but is still well within the range of acceptability. (iii) A more elaborate pseudo-Pareto formula is very accurate.

摘要

针对父母双方均患有该疾病轻度（或亚临床）形式的儿童中严重疾病发生概率的近似方法进行了一项研究。考虑了广泛的参数值范围。结果发现：（i）孟德尔 - 埃尔斯顿公式非常准确。（ii）简单的伪帕累托公式不如孟德尔 - 埃尔斯顿公式准确，但仍在可接受范围内。（iii）一个更精细的伪帕累托公式非常准确。