• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

逼近与疾病传播多因素模型特别相关的三变量正态概率。

Approximating a trivariate normal probability that is of special relevance to the multifactorial model of disease transmission.

作者信息

Hutchinson T P

出版信息

Ann Hum Genet. 1980 Jul;44(1):107-11. doi: 10.1111/j.1469-1809.1980.tb00950.x.

DOI:10.1111/j.1469-1809.1980.tb00950.x
PMID:7325595
Abstract

A study has been made of methods of approximating the probability of severe disease occurrence in the child of parents who both suffer from a mild (or subclinical) form of the disease in question. A wide range of parameter values has been considered. It has been found that (i) The Mendell-Elston formula is very accurate. (ii) The simple pseudo-Pareto formula is not quite as accurate as the Mendell-Elston, but is still well within the range of acceptability. (iii) A more elaborate pseudo-Pareto formula is very accurate.

摘要

针对父母双方均患有该疾病轻度(或亚临床)形式的儿童中严重疾病发生概率的近似方法进行了一项研究。考虑了广泛的参数值范围。结果发现:(i)孟德尔 - 埃尔斯顿公式非常准确。(ii)简单的伪帕累托公式不如孟德尔 - 埃尔斯顿公式准确,但仍在可接受范围内。(iii)一个更精细的伪帕累托公式非常准确。

相似文献

1
Approximating a trivariate normal probability that is of special relevance to the multifactorial model of disease transmission.逼近与疾病传播多因素模型特别相关的三变量正态概率。
Ann Hum Genet. 1980 Jul;44(1):107-11. doi: 10.1111/j.1469-1809.1980.tb00950.x.
2
Familial association of disease and the structure of trivariate distributions.疾病的家族关联性与三元分布结构
Ann Hum Genet. 1999 Nov;63(Pt 6):539-44. doi: 10.1017/S0003480099007836.
3
An easy method of calculating approximate recurrence risks using a multifactorial model of disease transmission.一种使用疾病传播多因素模型计算近似复发风险的简便方法。
Ann Hum Genet. 1980 Jan;43(3):285-93. doi: 10.1111/j.1469-1809.1980.tb01561.x.
4
On hereditary transmission in diseases of complex etiology.关于复杂病因疾病的遗传传递。
Prog Clin Biol Res. 1979;32:203-27.
5
Transmission probabilities are not correctly implemented in the computer program POINTER.传播概率在计算机程序POINTER中未得到正确实现。
Am J Hum Genet. 1991 Aug;49(2):459.
6
The incomplete, multiple ascertainment model: assumptions, applications, and alternative models.不完全多重确定模型:假设、应用及替代模型。
Genet Epidemiol. 1989;6(1):247-51. doi: 10.1002/gepi.1370060143.
7
Prediction of linkage phase by parental phenotypes.
Genet Epidemiol. 1996;13(3):271-83. doi: 10.1002/(SICI)1098-2272(1996)13:3<271::AID-GEPI4>3.0.CO;2-9.
8
A simple test for the aggregation of disease occurrence in genealogical data.一种用于检验系谱数据中疾病发生聚集性的简单测试。
Hum Hered. 1981;31(6):334-8. doi: 10.1159/000153234.
9
The transmission probability model is useful to prevent false inference.传输概率模型有助于防止错误推断。
Am J Hum Genet. 1993 Feb;52(2):441-2.
10
The heterogeneity problem. I: Separating genetic from environmental forms of the same disease.异质性问题。I:区分同一疾病的遗传形式与环境形式。
Am J Med Genet. 1985 Jun;21(2):357-71. doi: 10.1002/ajmg.1320210219.