[抗肿瘤抗生素橄榄霉素与镁离子的相互作用]
[Interaction of the antitumor antibiotic olivomycin with Mg2+ ions].
作者信息
Pitina L R, Baranov E P, Grinchenko B I, Brikenshteĭn B Kh, Barenboĭm G M
出版信息
Antibiotiki. 1981 Dec;26(12):906-12.
The study on the mechanisms of olivomycin and olivin interaction with the magnesium ions showed that formation of the olivomycin complexes with Mg2+ involved 2 stages. At the first (rapid) stage Mg2+ is attached to keto-oxygen of the aglycone polycyclic part. At the second (slow) stage the complex is relaxed into the stable state with a more compact configuration. the equilibrium constants (Ce) of the main processes of olivomycin and olivin interaction with Mg2+ were determined. In the first case Ce = 3 . 10(3) M+1 and in the second case Ce = 1.6 . 10(2) M-1. It was shown that the geometric and optic characteristics of the complexes were consistently related: formation of the stable complex was accompanied by a 10-time decrease in the fluorescence quantum efficiency.
对橄榄霉素和橄榄菌素与镁离子相互作用机制的研究表明，橄榄霉素与Mg2+形成复合物涉及两个阶段。在第一（快速）阶段，Mg2+附着于苷元多环部分的酮氧上。在第二（缓慢）阶段，复合物松弛成构型更紧密的稳定状态。测定了橄榄霉素和橄榄菌素与Mg2+主要相互作用过程的平衡常数（Ce）。第一种情况下Ce = 3×10³ M⁻¹，第二种情况下Ce = 1.6×10² M⁻¹。结果表明，复合物的几何和光学特征始终相关：稳定复合物的形成伴随着荧光量子效率下降10倍。
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