Ghetti B, Fuller R W, Sawyer B D, Hemrick-Luecke S K, Schmidt M J
Brain Res Bull. 1981 Dec;7(6):711-4. doi: 10.1016/0361-9230(81)90123-4.
Purkinje cells in the cerebellum receive inhibitory noradrenergic input from the locus coeruleus. In pcd mutant mice all Purkinje cells degenerate by 45 days of age. The purpose of the present studies was to determine if the loss of these cerebellar neurons affects the amounts of norepinephrine in the cerebellum of mice 25-280 days of age. No significant changes in norepinephrine content were detected during or after Purkinje cell degeneration. However, since degeneration led to a reduction in cerebellar weight, the norepinephrine concentration was increased in pcd mutants. These results indicate that despite the loss of a major postsynaptic target (Purkinje cells), the cerebellar noradrenergic input remains stable.
小脑浦肯野细胞接收来自蓝斑核的抑制性去甲肾上腺素能输入。在pcd突变小鼠中，所有浦肯野细胞在45日龄时都会退化。本研究的目的是确定这些小脑神经元的丧失是否会影响25至280日龄小鼠小脑中去甲肾上腺素的含量。在浦肯野细胞退化期间或之后，未检测到去甲肾上腺素含量的显著变化。然而，由于退化导致小脑重量减轻，pcd突变体中的去甲肾上腺素浓度升高。这些结果表明，尽管主要突触后靶点（浦肯野细胞）丧失，但小脑去甲肾上腺素能输入仍保持稳定。
