Kelley K O, Gould K L
Cardiovasc Res. 1981 Nov;15(11):615-22. doi: 10.1093/cvr/15.11.615.
The metabolic and nonmetabolic components of reactive hyperaemia were separated by comparing the coronary blood flow response after total occlusion to that after perfusion of equal duration with deoxygenated blood at normal aortic pressure in 15 open chest dogs. The flow repayment after 10 and 15 s perfusions with deoxygenated blood was a third to a quarter of that following 10 and 15 S total occlusion (P = 0.0001) and also less than the calculated normoxic flow debt (0.96 +/- 0.09 and 0.82 +/- 0.16, respectively), indicating no over-repayment. The flow repayment after deoxygenated perfusion was not reduced by increasing the flow rate during the perfusion, suggesting that our results were not due to increased washout rates of vasodilator metabolites during the perfusion. We conclude that reactive hyperaemia following brief total occlusion differs significantly from hyperaemia following deoxygenated perfusion and that this difference is probably due to the mechanical effect of sudden changes in coronary flow and perfusion pressure accompanying occlusion-release and is independent of myocardial oxygen supply.
通过比较15只开胸犬在完全闭塞后与在正常主动脉压下用脱氧血液进行等时长灌注后的冠状动脉血流反应，分离出反应性充血的代谢和非代谢成分。用脱氧血液灌注10秒和15秒后的血流恢复量分别为完全闭塞10秒和15秒后血流恢复量的三分之一至四分之一（P = 0.0001），且也低于计算出的常氧血流亏欠量（分别为0.96±0.09和0.82±0.16），表明不存在过度恢复。脱氧灌注后的血流恢复量不会因灌注期间流速增加而减少，这表明我们的结果并非由于灌注期间血管舒张代谢产物的清除率增加所致。我们得出结论，短暂完全闭塞后的反应性充血与脱氧灌注后的充血显著不同，这种差异可能是由于闭塞-释放时冠状动脉血流和灌注压力突然变化的机械效应，且与心肌氧供应无关。
