García-Barreto D, Toruncha A, Gonzalez-Gomez A, Llerena L, Groning E, Hernandez-Cañero A
Clin Cardiol. 1981 Nov-Dec;4(6):330-5. doi: 10.1002/clc.4960040605.
Acute antiarrhythmic drug testing with disopyramide was accomplished in 25 patients with frequent ventricular premature depolarization (VPD). Systolic time intervals (STI) were used to assess left ventricular performance. Eighteen patients responded after a loading oral dose of 300 mg disopyramide with 80% or greater reduction in VPD and abolition of advanced grades. Mean onset of drug action was 93 min and the mean plasma level at 2 h was 3.4 microgram /ml. During maintenance therapy 2 of the 18 patients had a relapse, In 2 others, initially protected, VPD recurred during both exercise and psychological stress testing. STI showed increments in pre-ejection period (PEP) and in PEP/ejection time ratio at peak concentrations of plasma disopyramide. Acute tests repeated with placebo in a single-blind fashion in responding patients failed to significantly reduce VPD frequency or grade. Side effects consisted of anticholinergic actions of disopyramide. In 3 patients aggravation of heart failure compelled discontinuation of disopyramide which then remitted.
对25例频发室性早搏（VPD）患者进行了丙吡胺急性抗心律失常药物试验。采用收缩期时间间期（STI）评估左心室功能。18例患者口服300mg丙吡胺负荷剂量后有反应，VPD减少80%或更多，高级别室性早搏消失。药物作用的平均起效时间为93分钟，2小时时的平均血浆水平为3.4微克/毫升。在维持治疗期间，18例患者中有2例复发，另外2例最初得到保护，但在运动和心理应激试验期间VPD复发。在血浆丙吡胺浓度峰值时，STI显示射血前期（PEP）和PEP/射血时间比值增加。对有反应的患者以单盲方式用安慰剂重复急性试验，未能显著降低VPD频率或级别。副作用包括丙吡胺的抗胆碱能作用。3例患者心力衰竭加重，被迫停用丙吡胺，随后病情缓解。
