Cramers M, Thormann J
Contact Dermatitis. 1981 Jul;7(4):189-91. doi: 10.1111/j.1600-0536.1981.tb04040.x.
Patch tests with a cream (Calmuril) containing 10% urea were performed on 79 patients with eczematous skin disease; seven (9.9%) had positive tests. Patch tests with the ingredients of the cream were negative. It is suggested that the positive patch test reactions are toxic, due to hypertonicity and acidity of the cream.
对79例患有湿疹性皮肤病的患者进行了使用含10%尿素的乳膏（Calmuril）的斑贴试验；7例（9.9%）试验呈阳性。对该乳膏的成分进行斑贴试验结果为阴性。提示斑贴试验阳性反应是由于该乳膏的高渗性和酸性导致的毒性反应。
