Sanchez-Chapula J
Eur J Pharmacol. 1981 Sep 11;74(2-3):253-6. doi: 10.1016/0014-2999(81)90539-2.
In electrically stimulated strip from right guinea-pig atria histamine produced a positive inotropic effect and it increased the amplitude and duration of calcium-dependent slow action potentials, which suggests an increase in the slow inward current. These effects were apparently mediated by H2-receptors. On strips from left atria histamine produced an H1-receptor mediated positive inotropic effect, without alteration of slow action potentials. The mechanism of this positive inotropic effect remains unknown.
在对来自右豚鼠心房的条带进行电刺激时，组胺产生了正性肌力作用，并增加了钙依赖性慢动作电位的幅度和持续时间，这表明内向慢电流增加。这些效应显然是由H2受体介导的。在来自左心房的条带上，组胺产生了一种由H1受体介导的正性肌力作用，而慢动作电位没有改变。这种正性肌力作用的机制尚不清楚。
