免疫调节化合物BM 12.531（阿齐美松）对小鼠辐射抗性和粒细胞生成集落形成单位的影响。
Influence of the immunomodulating compound BM 12.531 (azimexone) on radioresistance and granulopoietic colony forming units in mice.
作者信息
Gassel W D, Laukel H, Braun R, Werner T, Bicker U
出版信息
Exp Pathol. 1981;20(2):105-7. doi: 10.1016/s0232-1513(81)80017-5.
PMID:7327218
Abstract
BM 12.531 (azimexone) increases the survival of mice exposed to 650 rad. Levamisole, isoprenosine or aristolochia acid have no effects in this system. After administration of 25 mg/kg azimexone to C57 Bl/6-mice a statistically significant increase in CFUc was found. Maybe this increase in CFUc can explain the radioprotective effect of azimexone.
摘要
BM 12.531（阿齐美克松）可提高暴露于650拉德辐射的小鼠的存活率。左旋咪唑、异丙肌苷或马兜铃酸在该系统中无作用。给C57 Bl/6小鼠注射25毫克/千克阿齐美克松后，发现集落形成单位（CFUc）有统计学意义的增加。CFUc的这种增加或许可以解释阿齐美克松的辐射防护作用。
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