Beelen R H
Haematol Blood Transfus. 1981;27:89-100. doi: 10.1007/978-3-642-81696-3_10.
The development of the pattern of peroxidatic activity (PA) has been studied in vivo and in vitro in macrophages and other mononuclear phagocytes. In vivo in the animal model the macrophages show four different PA patterns characterizing exudate macrophages, exudate-resident macrophages, resident macrophages and PA-negative macrophages. Cultured in vitro, rat and human blood monocytes and rat, mouse and human exudate macrophages acquire the characteristic PA pattern of resident macrophages via the transitional stage of cells with the characteristics of exudate-resident macrophages. The cytochemistry, the occurrence of this cell type in vivo and the kinetics in vitro indicate that exudate-resident macrophages represent a transitional form between the exudate and the resident macrophages. The results obtained in vivo and in vitro strongly suggest that divergent PA patterns of mononuclear phagocytes represent differences in the stages of development of these cells in the sequence monoblast - promonocyte - monocyte - exudate macrophage - exudate - resident macrophage - resident macrophage. Moreover, PA-negative cells may in fact represent, firstly, another transitional stage between exudate and resident cells and, secondly, an end-stage macrophage in vitro.
已在体内和体外对巨噬细胞及其他单核吞噬细胞中过氧化物酶活性（PA）模式的发展进行了研究。在动物模型体内，巨噬细胞呈现出四种不同的PA模式，分别表征渗出性巨噬细胞、渗出性驻留巨噬细胞、驻留巨噬细胞和PA阴性巨噬细胞。在体外培养时，大鼠和人类血液单核细胞以及大鼠、小鼠和人类渗出性巨噬细胞会通过具有渗出性驻留巨噬细胞特征的细胞过渡阶段，获得驻留巨噬细胞的特征性PA模式。细胞化学、这种细胞类型在体内的出现情况以及体外动力学表明，渗出性驻留巨噬细胞代表了渗出性巨噬细胞和驻留巨噬细胞之间的过渡形式。体内和体外获得的结果有力地表明，单核吞噬细胞不同的PA模式代表了这些细胞在单核母细胞 - 前单核细胞 - 单核细胞 - 渗出性巨噬细胞 - 渗出性驻留巨噬细胞 - 驻留巨噬细胞这一序列中发育阶段的差异。此外，PA阴性细胞实际上可能首先代表渗出性细胞和驻留细胞之间的另一个过渡阶段，其次代表体外的终末阶段巨噬细胞。
