Gaffney P J, Joe F, Rowe E A, Whitaker A N
Haemostasis. 1981;10(6):304-14. doi: 10.1159/000214416.
The lysis rates of 125I cross-linked plasma fibrin clots have been investigated following immersion in various buffered concentration of streptokinase (SK), prior to (called the SK leads to plgn regimen) and after (called the plgn leads to SK regimen) enrichment with 2.0 U of plasminogen (plgn, lys-type). The SK leads to plgn regimen usually achieved total clot lysis with the most active lysis occurring following enrichment in 125-130 IU SK solutions, while only partial lysis was observed during the plgn leads to SK procedure. The effect of SK concentration was marked during the SK leads to plgn regimen while, during the plgn leads to SK treatment, its lytic rate never exceeded a factor of 2.0 over a wide concentration range of SK (8.0-20,000 IU/ml. The availability of plasminogen to perfuse the activator-rich clot seemed to be the prevailing influence on clot lysis and lysis of clots in plasma was inhibited by serum inhibitors, SK antibodies and plasma fibrinogen.
在富含2.0单位纤溶酶原（纤溶酶原，赖氨酸型）之前（称为SK诱导纤溶酶原方案）和之后（称为纤溶酶原诱导SK方案），将125I交联的血浆纤维蛋白凝块浸入不同缓冲浓度的链激酶（SK）中后，研究了其溶解率。SK诱导纤溶酶原方案通常能实现凝块完全溶解，在125 - 130 IU SK溶液中富集后，溶解活性最高，而在纤溶酶原诱导SK过程中仅观察到部分溶解。在SK诱导纤溶酶原方案期间，SK浓度的影响显著，而在纤溶酶原诱导SK治疗期间，在较宽的SK浓度范围（8.0 - 20,000 IU/ml）内，其溶解率从未超过2.0倍。纤溶酶原灌注富含激活剂凝块的可用性似乎是对凝块溶解的主要影响因素，血浆中的血清抑制剂、SK抗体和血浆纤维蛋白原会抑制凝块溶解。
