Kaga A
Hokkaido Igaku Zasshi. 1981 Mar;56(2):159-75.
In the present studies, rats are fed with four different kinds of diet; (i) normal diet, (ii) B2-deficient diet, (iii) B2-tetrabutyrate added normal diet, and (iv) B2-tetrabutyrate added B2-deficient diet. The number or rats in each group is 10 and the term of raising is 18 to 46 days. In the normal diet group, when exposed to 90% oxygen, cholesterol, triglycerides, and the TBA value are increased in blood serum. The addition of B2-tetrabutyrate in diets reduces these elevation. Through electron microscope observation, oxygen exposure leads to puffing of mitochondria and increasing lipofuscin granules in livers and lungs. The destruction of mitochondria is also observed in brain. The addition of B2-teterabutyrate reduces the destruction of mitochondria and suppresses formation of lipofuscin.
在目前的研究中，给大鼠喂食四种不同的饮食；（i）正常饮食，（ii）缺乏维生素B2的饮食，（iii）添加了维生素B2四丁酯的正常饮食，以及（iv）添加了维生素B2四丁酯的缺乏维生素B2的饮食。每组大鼠数量为10只，饲养期为18至46天。在正常饮食组中，当暴露于90%氧气环境时，血清中的胆固醇、甘油三酯和TBA值会升高。饮食中添加维生素B2四丁酯可降低这些升高值。通过电子显微镜观察，氧气暴露会导致肝脏和肺中的线粒体肿胀以及脂褐素颗粒增加。在大脑中也观察到线粒体的破坏。添加维生素B2四丁酯可减少线粒体的破坏并抑制脂褐素的形成。
