Montali R J, Bush M, Strandberg J D, Janssen D L, Boness D J, Whitla J C
J Am Vet Med Assoc. 1981 Dec 1;179(11):1198-202.
Dermatitis associated with Fusarium sp infection developed in 3 California sea lions (Zalophus californianus) and 3 gray seals (Halichoerus grypus) at the National Zoological Park in Washington DC. The lesions were papular or nodular and were distributed mainly on the face, trunk, and flippers. One sea lion died 6 weeks after extensive cutaneous involvement. The lesions regressed after 1 mild exacerabtion in the other 2 sea lions. In the gray seals, the skin condition appeared to worsen during the summer and to regress during the winter, despite oral and topical treatment with miconazole and thiabendazole. Fusarium sp was repeatedly isolated from biopsy specimens of lesions. Hyperplasia of epidermal and follicular epithelium was associated with acute and chronic inflammation and fungal hyphae. The species of the fungus in 1 of the gray seals was determined to be F solani, a type occasionally associated with keratitis and opportunistic infections in human beings. Initial excessive chlorination and high fluctuating pool temperatures attributed to a faulty water treatment system were considered as factors in promoting fungal growth.
华盛顿特区国家动物园的3只加利福尼亚海狮（加州海狗）和3只灰海豹身上出现了与镰刀菌属感染相关的皮炎。病变为丘疹或结节状，主要分布在面部、躯干和鳍状肢。1只海狮在皮肤广泛受累6周后死亡。另外2只海狮的病情在轻度加重一次后消退。在灰海豹中，尽管使用咪康唑和噻苯达唑进行了口服和局部治疗，但皮肤状况在夏季似乎恶化，在冬季则消退。从病变活检标本中多次分离出镰刀菌属。表皮和毛囊上皮增生与急性和慢性炎症以及真菌菌丝有关。其中1只灰海豹身上的真菌种类被确定为茄病镰刀菌，这是一种偶尔与人类角膜炎和机会性感染有关的类型。最初因水处理系统故障导致的过度氯化和游泳池水温的大幅波动被认为是促进真菌生长的因素。
