Tsuruo T, Naganuma K, Iida H, Yamori T, Tsukagoshi S, Sakurai Y
J Antibiot (Tokyo). 1981 Sep;34(9):1206-9. doi: 10.7164/antibiotics.34.1206.
Bestatin, a chemically defined immunostimulant of low molecular weight, suppressed the gradually-occurring lymph node metastasis of P388 leukemia in CDF1 mice when administered i.p. at the doses of 1 approximately 30 micrograms/mouse. It could not, however, suppress the established large metastasis of P388 leukemia. Lymph node cells isolated from the mice given bestatin i.p. at 1 and 30 microgram/mouse showed cytostatic activity against P388 leukemic cells in vitro than those from the untreated mice.
贝司他汀是一种化学结构明确的低分子量免疫刺激剂，当以1至30微克/小鼠的剂量腹腔注射给药时，可抑制CDF1小鼠中P388白血病逐渐发生的淋巴结转移。然而，它不能抑制已形成的P388白血病大转移灶。腹腔注射1微克/小鼠和30微克/小鼠贝司他汀的小鼠分离出的淋巴结细胞，与未处理小鼠的淋巴结细胞相比，在体外对P388白血病细胞表现出细胞抑制活性。
