Dieterich E, Goebel B, Gutjahr P
Monatsschr Kinderheilkd (1902). 1978 Dec;126(12):709-10.
A direct cytotoxic effect of vincristine on the neurons, especially the cerebral cortex is discussed in the literature. In 188 patients treated with vincristine we saw no so called "Vincristine-induced Encephalopathy". In 67 children investigated 5 weeks up to 2 years after the last vincristine-injection we found no changes in EEG-tracings which could be discussed as vincristine-induced.
文献中讨论了长春新碱对神经元，尤其是大脑皮层的直接细胞毒性作用。在188例接受长春新碱治疗的患者中，我们未观察到所谓的“长春新碱诱发的脑病”。在67名儿童中，于最后一次注射长春新碱后5周直至2年进行调查，我们发现脑电图记录没有可被认为是由长春新碱诱发的变化。
