Fiók J, Acs Z, Stark E
J Endocrinol. 1981 Dec;91(3):391-7. doi: 10.1677/joe.0.0910391.
Increasing the levels of endogenous gamma-aminobutyric acid (GABA) by treating rats with GABA-transaminase inhibitors (ethanolamine-O-sulphate and gamma acetylenic GABA) resulted in a decrease in plasma levels of GH. Diminishing GABAergic activity by inhibiting GABA synthesis with 3-mercaptopropionic acid or by blocking GABA receptors with bicuculline increased plasma concentration of GH. The presence of GABA was without effect on the basal, somatostatin-inhibited or high K+-stimulated secretion of GH by hemipituitary glands in vitro. The results suggest that GABA inhibits secretion of GH under the given experimental circumstances.
用γ-氨基丁酸转氨酶抑制剂（乙醇胺-O-硫酸盐和γ-乙炔基氨基丁酸）处理大鼠，提高内源性γ-氨基丁酸（GABA）水平，导致生长激素（GH）血浆水平降低。用3-巯基丙酸抑制GABA合成或用荷包牡丹碱阻断GABA受体来降低GABA能活性，会增加GH的血浆浓度。GABA的存在对体外半垂体的基础、生长抑素抑制或高钾刺激的GH分泌没有影响。结果表明，在给定的实验条件下，GABA抑制GH的分泌。
