离体大鼠心脏室颤模型。
A model of ventricular fibrillation in the isolated rat heart.
作者信息
Woodward B
出版信息
J Pharmacol Methods. 1981 Nov;6(3):219-31. doi: 10.1016/0160-5402(81)90111-x.
PMID:7329071
Abstract
A simple technique is described for the induction of reversible ventricular fibrillation in the isolated rat heart. Fibrillation is induced by doubling the calcium chloride and halving the sodium chloride concentration of the perfusate. Fibrillation can be prevented by Class I antiarrhythmic drugs and verapamil.
摘要
描述了一种在离体大鼠心脏中诱导可逆性心室颤动的简单技术。通过将灌注液中氯化钙浓度加倍并将氯化钠浓度减半来诱导颤动。I类抗心律失常药物和维拉帕米可预防颤动。
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