Experimental electroencephalographic study of piracetam in cats.

In connection with some contradictions in the electroencephalographic data for piracetam, further investigations have been carried out to study its effect on the spontaneous and evoked EEG in intact cats after single and a 10-day administration of the drug. On the basis of analysis of the electroencephalogram using an ISEMA frequency-amplitude analyser, the values of the frequency ranges and those of the mean amplitude were averaged by use of FACOM computer. The results from our experiments indicate that no visual differences in the spontaneous and evoked EEG after piracetam administration have been observed. The spontaneous activity after the 10-day treatment with 1000 mg/kg i.m. quantitatively shows an increase of the fast frequencies (beta and alpha waves), increase of the mean amplitude, and increase of the evoked activity after visual and sound stimulation. An involvement of deep structures in performing the effect of piracetam is admitted as well as kind of "augmentation" of the cerebral bioelectrical activity.