Determination of plasma concentrations of underivatized cyclophosphamide by capillary gas chromatography.
作者信息
van den Bosch N, Driessen O, Emonds A, van Oosterom A T, Timmermans P J, de Vos D, Slee P H
出版信息
Methods Find Exp Clin Pharmacol. 1981 Nov-Dec;3(6):377-84.
PMID:7329162
Abstract
A sensitive method for the clinical determination of cyclophosphamide in 0.2 ml plasma by capillary gas chromatography with nitrogen-phosphorus detection is described. A detection limit of 50 nl/ml is readily obtainable, which is sufficiently low to measure the cyclophosphamide concentrations occurring in clinical practice. The selection of internal standards and the use of the nitrogen-phosphorus detection system is discussed, as well as eventualities for determination of cyclophosphamide metabolites.
摘要
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