Maruta T, Swanson D W
Pain. 1981 Dec;11(3):389-96. doi: 10.1016/0304-3959(81)90638-2.
In a pain management program (200 patients), a group of daily users of oxycodone compound (29 patients) and a subgroup who were taking a "high dose" of oxycodone compound (13 patients) were compared with a group of 171 non-users of oxycodone compound. A significantly lower treatment success rate was observed in the users (P = 0.04) and high-dose users (P = 0.03). A similar trend was seen in preliminary data available in a larger sample (514 patients). Continued study of these findings is necessary. Meanwhile, in patients with chronic pain, there should be cautious use of this compound.
在一个疼痛管理项目（200名患者）中，将一组每日使用羟考酮复方制剂的患者（29名）以及服用“高剂量”羟考酮复方制剂的一个亚组患者（13名）与171名未使用羟考酮复方制剂的患者进行了比较。使用者（P = 0.04）和高剂量使用者（P = 0.03）的治疗成功率显著较低。在一个更大样本（514名患者）的初步数据中也观察到了类似趋势。有必要对这些发现进行持续研究。同时，对于慢性疼痛患者，应谨慎使用该复方制剂。
