Jovanović V, Konstantinovska D, Milivojević K, Bzenić J
Nuklearmedizin. 1981 Dec;20(6):279-82.
Labelling yield and radiochemical purity, higher than 95%, of 99mTc-colloid preparations were determined by using the paper chromatography method. Less than 3% of labelled citric acid, added to the preparation as a buffer solution, has been found in 99mTc-sulphur colloid. High radiochemical purity and optimum size of colloid particles has also been proved by biodistribution studies on experimental animals. The analysis performed has shown that more than 50% of 99mTc-colloid preparations excreted by urine is 99mTcO-, the remaining past 50% being protein bound 99mTc. Biological half-time of excretion of the fast phase is the same for both preparations, i.e. 10 min, while for the slow component it is 120 min in 99mTc-S-colloid and 160 min in 99mTc-Sn colloid.
采用纸色谱法测定了99mTc-胶体制剂的标记产率和放射化学纯度，均高于95%。在99mTc-硫胶体中发现，作为缓冲溶液添加到制剂中的标记柠檬酸含量低于3%。对实验动物的生物分布研究也证明了其具有高放射化学纯度和最佳的胶体颗粒大小。所进行的分析表明，经尿液排出的99mTc-胶体制剂中，超过50%为99mTcO-，其余超过50%为蛋白结合型99mTc。两种制剂快速相排泄的生物半衰期相同，均为10分钟，而对于慢成分，99mTc-S-胶体为120分钟，99mTc-Sn胶体为160分钟。
