Hamilton D V, Pryor J S
Postgrad Med J. 1981 Mar;57(665):167-71. doi: 10.1136/pgmj.57.665.167.
Endocrine abnormalities in 73 patients with primary hyperparathyroidism were studied: 8 patients were diabetic, 3 were thyrotoxic, 2 were hypothyroid, and one had a gastrinoma and carcinoid tumour. In 9 of these patients, carbohydrate metabolism and thyroid function were studied in detail pre- and 3 months postoperatively. In 6 patients following a glucose load, insulin concentrations were markedly elevated pre-operatively when compared with those found postoperatively. Likewise, in 7 patients, serum thyroxine was greater pre- than postoperatively. The aetiology of these changes and their relevance to the management of patients with primary hyperparathyroidism is discussed.
对73例原发性甲状旁腺功能亢进患者的内分泌异常情况进行了研究:8例患者患有糖尿病,3例为甲状腺毒症,2例甲状腺功能减退,1例患有胃泌素瘤和类癌肿瘤。对其中9例患者在术前及术后3个月详细研究了碳水化合物代谢和甲状腺功能。在6例患者中,葡萄糖负荷后,术前胰岛素浓度与术后相比明显升高。同样,7例患者术前血清甲状腺素水平高于术后。本文讨论了这些变化的病因及其与原发性甲状旁腺功能亢进患者管理的相关性。