McDougald L R, Keshavarz K, Rosenstein M
Poult Sci. 1981 Nov;60(11):2416-22. doi: 10.3382/ps.0602416.
Five experiments were conducted to test the anticoccidial efficacy of salinomycin (AHR-3096C, A. H. Robins) at 66 ppm and its compatibility with roxarsone (50 ppm) under floor pen conditions Monensin (100, 121 ppm), lasalocid (75, 125 ppm), and shuttle programs of salinomycin-monensin (66/100 ppm) or monensin-salinomycin (100/66 ppm) were included for comparison. Coccidiosis exposure was provided by using the infected seeder bird technique. Salinomycin reduced the lesion scores significantly and improved the body weight and feed conversion in all the trials as compared to unmedicated groups. All three ionophores effectively reduced the lesion scores. Birds treated with salinomycin-monensin shuttle programs had lesion scores, body weight, and feed conversion that were not significantly different from the salinomycin treated birds, suggesting that this shuttle program could be used satisfactorily for control of coccidiosis. Lesion scores, body weight, and feed conversion data of the 4th and 5th trials suggested that the anticoccidial activity of salinomycin and roxarsone are additive. There was evidence of compensatory growth after withdrawal of salinomycin and monensin but not with lasalocid.
进行了五项试验，以测试在地面平养条件下，66 ppm的盐霉素（AHR - 3096C，A. H. 罗宾斯公司）的抗球虫效力及其与50 ppm洛克沙胂的相容性。同时纳入莫能菌素（100、121 ppm）、拉沙洛西（75、125 ppm）以及盐霉素 - 莫能菌素（66/100 ppm）或莫能菌素 - 盐霉素（100/66 ppm）穿梭方案进行比较。通过使用感染种禽技术来提供球虫病感染。与未用药组相比，在所有试验中，盐霉素均显著降低了病变评分，并改善了体重和饲料转化率。所有三种离子载体均有效降低了病变评分。接受盐霉素 - 莫能菌素穿梭方案处理的鸡只，其病变评分、体重和饲料转化率与盐霉素处理的鸡只相比无显著差异，这表明该穿梭方案可用于球虫病的满意控制。第4次和第5次试验的病变评分、体重和饲料转化率数据表明，盐霉素和洛克沙胂的抗球虫活性具有相加性。有证据表明，停用盐霉素和莫能菌素后会出现补偿性生长，但拉沙洛西则不会。
