Vascular stability and middle molecules removal in hypertonic haemodiafiltration.

Hypertonic haemodiafiltration is a simultaneous hypertonic (delta 550, Na 275mEq/L) low volume (7.2 litres) haemofiltration and hypotonic (delta 282) short time (180') haemodialysis. Reduction of the predialysis body pool of MM (-48 per cent) and small molecules (-33 per cent) was obtained. No relationship between vascular stability and MM removal was observed. However, a net UF of 20.5ml/min and a greater removal of solutes up to 1500 daltons mw were obtained with a three hours thrice weekly dialysis programme.