Yoda Y, Abe T
Thromb Haemost. 1981 Dec 23;46(4):706-9.
FPA level, fibrinogen turnover rate, and fibrinolytic activity were studied on 18 patients with malignant disease. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r = 0.74, p less than 0.001) and FDP (r - 0.58, p less than 0.02). Estimated FPA turnover rate was also correlated with fibrinogen turnover rate (r = 0.70, p less than 0.001). These results suggest that fibrinogen catabolism in patients with malignant disease is related with thrombin proteolysis. However, ratios of 1/2 FPA turnover rate to fibrinogen turnover rate suggest that intravascular thrombin proteolysis is not the major determinant of fibrinogen catabolism. It is suspected that extravascular thrombin proteolysis is responsible for the elevation of plasma FPA level which is correlated with acceleration of fibrinogen catabolism.
对18例恶性疾病患者的纤维蛋白肽A（FPA）水平、纤维蛋白原周转率和纤溶活性进行了研究。结果发现，FPA水平显著升高，且与纤维蛋白原周转率相关（r = 0.74，p＜0.001）以及与纤维蛋白降解产物（FDP）相关（r = 0.58，p＜0.02）。估计的FPA周转率也与纤维蛋白原周转率相关（r = 0.70，p＜0.001）。这些结果表明，恶性疾病患者的纤维蛋白原分解代谢与凝血酶蛋白水解有关。然而，FPA周转率与纤维蛋白原周转率的比值表明，血管内凝血酶蛋白水解不是纤维蛋白原分解代谢的主要决定因素。怀疑血管外凝血酶蛋白水解是导致血浆FPA水平升高的原因，而血浆FPA水平升高与纤维蛋白原分解代谢加速相关。
