Yang T S, Chi C C, Tsai C J, Chang M J
Obstet Gynecol. 1978 Dec;52(6):682-4.
A case is presented of fetal teratogenic damage from an unusually high maternal dosage of diphenylhydantoin, 600 mg daily, to a 40-kg woman throughout pregnancy. The anomalies included narrowed ends of the fingers and toes; aplasia of the nails on the other fingers and toes; aplasia of the distal phalanges of the fingers and toes; a broad, depressed nasal bridge; anteverted nostrils; prominent upper lip; coarse, profuse scalp hair; pilonidal sinus; and simian crease of the left hand. At the age of 7 months, ossification of the distal phalanges of both middle fingers appeared, the anterior fontanel was small, brain development was retarded, cranial asymmetry was marked, and the fingertips showed a pattern of low arch dermal ridges.
本文报告了一例胎儿致畸损伤病例，一名体重40公斤的女性在整个孕期每天服用600毫克苯妥英钠，剂量异常高。异常情况包括手指和脚趾末端变窄；其他手指和脚趾指甲发育不全；手指和脚趾远端指骨发育不全；鼻梁宽阔且凹陷；鼻孔前倾；上唇突出；头皮毛发粗糙且浓密；骶尾部窦；以及左手猿线。7个月大时，双手中指远端指骨出现骨化，前囟门小，脑发育迟缓，颅骨不对称明显，指尖呈现低弓状皮嵴图案。
