儿童期早期的湿疹和特应性：空肠黏膜中IgA浆细胞计数低。
Eczema and atopy in early childhood: low IgA plasma cell counts in the jejunal mucosa.
作者信息
Sloper K S, Brook C G, Kingston D, Pearson J R, Shiner M
出版信息
Arch Dis Child. 1981 Dec;56(12):939-42. doi: 10.1136/adc.56.12.939.
Abstract
Twenty-one children aged between 2 and 54 months, 14 with eczema and 7 with allergies in first-degree relatives, were referred for diagnostic jejunal mucosal biopsy for a variety of symptoms. A partial villous atrophy was found in 19 of the 21 biopsies obtained; the other 2 were normal. We report a highly significant (P less than 0.0001) lower IgA cell count in biopsies with partial villous atrophy compared with the results of our previous study of IgA and IgM plasma cells in the mucosal biopsies in children without eczema or a history of atopy matched for age and histological appearances. The IgM cell count was also lower.
摘要
21名年龄在2至54个月之间的儿童因各种症状被转诊进行诊断性空肠黏膜活检，其中14名患有湿疹，7名一级亲属有过敏史。在获取的21份活检样本中，有19份发现部分绒毛萎缩；另外2份正常。我们报告，与我们之前对年龄和组织学表现相匹配的无湿疹或特应性病史儿童的黏膜活检中IgA和IgM浆细胞的研究结果相比，部分绒毛萎缩的活检样本中IgA细胞计数显著降低（P小于0.0001）。IgM细胞计数也较低。
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