Rosekrans P C, Lindeman J, Meijer C J
Virchows Arch A Pathol Anat Histol. 1981;393(2):145-51. doi: 10.1007/BF00431071.
Jejunal mucosa biopsies from non-immune deficient patients with Giardia lamblia infestation were examined and showed three different groups of mucosal changes, distinguishable on morphological and immunohistochemical grounds. In three patients no morphological or immunohistochemical abnormalities were found (group A). In five patients a normal villous architecture was seen. These biopsies had increased numbers of interepithelial lymphocytes and of immunoglobulin containing cells in the lamina propria, with a relative increase of the number of IgA and IgG containing cells (group B). Two patients with a malabsorption syndrome due to giardiasis had marked villous atrophy, documented by morphometric measurements and large numbers of interepithelial lymphocytes and of immunoglobulin containing cells in the lamina propria, especially IgA and IgG (group C). These findings differ considerably from those in patients with immunodeficiency or gluten sensitive enteropathy. This suggests that when villous atrophy of the jejunal mucosa is found immunohistochemistry of jejunal biopsy specimens may be helpful in the differential diagnosis between mere giardiasis and giardiasis superimposed on immunodeficiency or gluten sensitive enteropathy.
对感染蓝氏贾第鞭毛虫的非免疫缺陷患者的空肠黏膜活检样本进行了检查，结果显示存在三组不同的黏膜变化，可通过形态学和免疫组织化学方法加以区分。三名患者未发现形态学或免疫组织化学异常（A组）。五名患者的绒毛结构正常。这些活检样本的上皮间淋巴细胞数量以及固有层中含免疫球蛋白的细胞数量增加，其中含IgA和IgG的细胞数量相对增多（B组）。两名因贾第虫病导致吸收不良综合征的患者出现明显的绒毛萎缩，形态计量学测量证实了这一点，固有层中有大量上皮间淋巴细胞和含免疫球蛋白的细胞，尤其是IgA和IgG（C组）。这些发现与免疫缺陷或麸质敏感性肠病患者的情况有很大不同。这表明，当发现空肠黏膜绒毛萎缩时，空肠活检标本的免疫组织化学检查可能有助于鉴别单纯贾第虫病与叠加免疫缺陷或麸质敏感性肠病的贾第虫病。
