Dunnington E A, White J M, Vinson W E
Can J Genet Cytol. 1981;23(3):545-55. doi: 10.1139/g81-060.
Randomly bred ICR mice were selected for five generations for high and low serum cholesterol (SC), voluntary physical activity, 56-day body weight and feed intake. An unselected, randomly bred control line was maintained with each pair of selection lines. Significant increases in mature body weight occurred in males of high weight and high intake lines and in females of high SC, high weight and high intake lines. Significant decreases in mature body weights occurred in males of low weight line and in females of low SC and low weight lines. Both high and low selected SC lines had greater (P less than 0.05) activity scores and consumed more feed than the SC control. Mice selected for high activity consumed more (P less than 0.05) feed than mice selected for low activity. Mice selected for high 56-day body weight consumed more (P less than 0.05) feed and had higher SC than mice selected for low 56-day body weight. Mice selected for high feed intake were heavier (P less than 0.05) and more active (P less than 0.05) than low feed intake mice but had significantly lower SC levels.
随机繁殖的ICR小鼠被选作五代，用于研究高、低血清胆固醇（SC）、自主身体活动、56日龄体重和采食量。每对选择品系都维持一个未选择的随机繁殖对照品系。高体重和高采食量品系的雄性以及高SC、高体重和高采食量品系的雌性成熟体重显著增加。低体重品系的雄性以及低SC和低体重品系的雌性成熟体重显著降低。高、低选择的SC品系都比SC对照具有更高（P<0.05）的活动评分，且消耗更多饲料。选择高活动量的小鼠比选择低活动量的小鼠消耗更多（P<0.05）饲料。选择56日龄高体重的小鼠比选择56日龄低体重的小鼠消耗更多（P<0.05）饲料且具有更高的SC。选择高采食量的小鼠比低采食量小鼠更重（P<0.05）且更活跃（P<0.05），但SC水平显著更低。
