空气过敏原在哮喘死亡流行中可能扮演的角色。

The possible role of aero-allergens in the epidemic of asthma deaths.

作者信息

Jenkins P F, Mullins J K, Davies B H, Williams D A

出版信息

Clin Allergy. 1981 Nov;11(6):611-20. doi: 10.1111/j.1365-2222.1981.tb02182.x.

DOI:10.1111/j.1365-2222.1981.tb02182.x

Abstract

The 'epidemic' of asthma deaths observed in the mid 1960s remains unexplained; various aetiological factors having been suggested. We suggest that aero-allergenic factors may have been important based on an analysis of aero-allergens in Cardiff over a 17-year period: a striking temporal association exists between the concentration of hyaline ascospores and increased asthma deaths. These spores, which are particularly prevalent in the summer months, have been inadequately studied as a cause of severe asthma.

摘要

20世纪60年代中期观察到的哮喘死亡“流行”现象仍无法解释；人们已提出了各种病因因素。基于对加的夫17年间空气过敏原的分析，我们认为空气过敏原因素可能很重要：透明子囊孢子浓度与哮喘死亡增加之间存在显著的时间关联。这些孢子在夏季尤为普遍，但作为严重哮喘的病因尚未得到充分研究。