Horiuchi K, Yokoyama A, Tanaka H, Saji H, Odori T, Morita R, Torizuka K
Eur J Nucl Med. 1981 Dec;6(12):567-72. doi: 10.1007/BF00252671.
99mTc-Pyridoxylidene-glutamate (Tc-PG) was introduced in 1975 by Baker et al. as a cholescintigraphic agent. Nevertheless its routine use has been limited due to the autoclaving process involved. To shorten the labeling procedure, an analysis of Tc-PG complex formation using the stannous chloride method was carried out. Sn-Resin (stannous ion adsorbed onto cation exchange resin) was used for labeling a stable Tc-PG with high efficiency. A preautoclaved complex of pyridoxal and glutamate was required but the labeling procedure took only 10-15 min after the elution of 99m-TcO4- from the generator. Formation of a complex other than a 99mTc-complex of the Schiff -base ligand pyridoxylidene-glutamate is discussed. The new formulation of a Tc-PG kit (Sn-Resin) simplified the labeling method and reproducible data to that already reported by Baker was obtained in chromatographic studies. Its suitability in hospital departments has already been shown in clinical studies.
1975年，贝克等人将99m锝 - 吡哆醛谷氨酸盐（Tc - PG）作为一种胆系闪烁造影剂引入。然而，由于涉及高压灭菌过程，其常规应用受到限制。为缩短标记程序，使用氯化亚锡法对Tc - PG络合物的形成进行了分析。锡树脂（吸附在阳离子交换树脂上的亚锡离子）用于高效标记稳定的Tc - PG。需要一个预先高压灭菌的吡哆醛和谷氨酸的络合物，但在从发生器洗脱99m锝酸盐后，标记程序仅需10 - 15分钟。讨论了除了席夫碱配体吡哆醛谷氨酸盐的99m锝络合物之外的其他络合物的形成。Tc - PG试剂盒（锡树脂）的新配方简化了标记方法，并在色谱研究中获得了与贝克已报道的结果具有可比性的可重复数据。其在医院科室的适用性已在临床研究中得到证实。
