Bard J W
Dermatologica. 1981;163(5):376-84. doi: 10.1159/000250189.
23 clinically and pathologically typical lesions of chondrodermatitis nodularis chronica helicis occurring in 19 patients are reviewed. The lesions seem to fit well with the clinical and pathologic findings of diseases of transepidermal elimination. Clinically, one finds exceedingly chronic tender nodules of the ear with a central horny plug. Histologically, there is epidermal hyperplasia around an area in the upper dermis which displays fibrinoid material and/or necrobiotic collagen with the formation of a sinus tract through the epidermis. Although the derangement of the collagen in the upper dermis seems to be the inciting factor in producing transepidermal elimination, other factors such as anatomy, vascular deficiency and trauma are also important in pathogenesis.
回顾了19例患者身上出现的23处临床及病理表现典型的慢性结节性耳轮软骨皮炎病变。这些病变似乎与经表皮排除性疾病的临床和病理表现非常吻合。临床上,可见耳部出现极度慢性的压痛性结节,中央有角质栓。组织学上,真皮上层某区域周围有表皮增生,该区域显示有纤维蛋白样物质和/或坏死性胶原,并形成一条穿过表皮的窦道。虽然真皮上层胶原的紊乱似乎是导致经表皮排除的激发因素,但其他因素如解剖结构、血管缺乏和创伤在发病机制中也很重要。