Ching M
J Endocrinol Invest. 1981 Oct-Dec;4(4):389-92. doi: 10.1007/BF03348300.
Barbital (diethylbarbituric acid), administered via the drinking water (0.1% solution), elicited mild goitrogenic responses in rats (p less than 0.05), accompanied by a slight depression in serum T4 titers (p less than 0.02). The goitrogenic responses appeared to be the result of slight elevations in the serum TSH levels and in the case of neonate rats, whose mothers were fed barbital during pregnancy and lactation, the elevations of TSH in the circulation were pronounced (p less than 0.01). However, continuation of barbital treatment beyond puberty resulted in mean serum TSH titers declining to twice the mean control values so that only the variances between the data were different(p less than 0.05). This group of young adults showed endocrine profiles which resembled those of more mature rats. The latter group included the mothers of these young adults and of the neonates. In contrast to the action of barbital, feeding rats 0.05% propylthiouracil (PTU) in the drinking water caused substantial increases in mean serum levels of TSH (p less than 0.001) and goiter size (p less than 0.001). Moreover, the precipitous declines in serum T4 elicited by PTU were of far greater magnitude than that caused by barbital (p less than 0.001).
通过饮用水给予大鼠巴比妥（二乙基巴比妥酸，0.1%溶液），可引发轻度甲状腺肿反应（p<0.05），同时血清T4滴度略有下降（p<0.02）。甲状腺肿反应似乎是血清促甲状腺激素（TSH）水平略有升高的结果，对于新生大鼠而言，其母亲在怀孕和哺乳期间喂食巴比妥，循环中TSH的升高更为明显（p<0.01）。然而，青春期后继续给予巴比妥治疗，导致血清TSH平均滴度降至对照平均值的两倍，因此仅数据之间的方差有所不同（p<0.05）。这群年轻成年大鼠的内分泌特征与更成熟大鼠的相似。后者包括这些年轻成年大鼠和新生大鼠的母亲。与巴比妥的作用相反，在饮用水中给大鼠喂食0.05%丙硫氧嘧啶（PTU）会导致血清TSH平均水平大幅升高（p<0.001）和甲状腺肿大小增加（p<0.001）。此外，PTU引起的血清T4急剧下降幅度远大于巴比妥所致（p<0.001）。
