Harding R, Poore E R, Cohen G L
J Dev Physiol. 1981 Aug;3(4):231-43.
Responses to brief episodes of occlusion of the middle uterine artery were examined in six fetal sheep in utero between 122 and 140 days of gestation. Continuous recordings were made of fetal breathing movements, electro-cortical (ECoG) and electro-ocular (EOG) activity, arterial pressure and heart rate. Five minutes of unilateral or bilateral arterial occlusion caused fetal hypoxaemia while changes in mean arterial PCO2 and pH were not statistically significant. Occlusions usually led to a cessation of rapid eye movements (REM) and respiratory activity (86% of trials), to the appearance of high-voltage slow waves in the ECoG (84% of trials) and to a fall in heat rate of more than 10% (81% of trials). With the exception of the changes in heart rate, these responses resemble those which frequently occur during non-labour contractions of the uterus. We conclude that the cessation of fetal breathing movements and rapid eye movements and the onset of slow waves in the ECoG seen in association with uterine contractions may be due to the mild hypoxaemia which accompanies them.
在妊娠122至140天的六只子宫内的胎羊中，研究了对子宫中动脉短暂阻塞发作的反应。连续记录胎儿呼吸运动、皮层电图（ECoG）和眼电图（EOG）活动、动脉压和心率。五分钟的单侧或双侧动脉阻塞导致胎儿低氧血症，而平均动脉血二氧化碳分压和pH值的变化无统计学意义。阻塞通常导致快速眼动（REM）和呼吸活动停止（86%的试验），ECoG中出现高电压慢波（84%的试验），心率下降超过10%（81%的试验）。除心率变化外，这些反应类似于子宫非分娩收缩期间频繁发生的反应。我们得出结论，与子宫收缩相关的胎儿呼吸运动和快速眼动停止以及ECoG中慢波的出现可能是由于伴随它们的轻度低氧血症。
