Messer A, Savage M, Carter T P
J Neurochem. 1981 Dec;37(6):1610-2. doi: 10.1111/j.1471-4159.1981.tb06335.x.
In the mouse cerebellar mutant staggerer, thymidine kinase levels do not increase developmentally at ages when the wild-type level is high. Mixing experiments show that this effect is not due to an endogenous inhibitor of the enzyme. Both the Km and the susceptibility of the thymidine kinase to nucleotide inhibitors are unaltered in the mutant animals, suggesting that the enzyme is not induced in the mutant.
在小鼠小脑突变体“蹒跚者”中，胸苷激酶水平在野生型水平较高的发育阶段并未升高。混合实验表明，这种效应并非由于该酶的内源性抑制剂所致。突变动物中胸苷激酶的米氏常数（Km）和对核苷酸抑制剂的敏感性均未改变，这表明该酶在突变体中未被诱导。
