L-抗坏血酸和泛酸钙对脱镁叶绿酸α和血卟啉诱导的光敏作用的预防效果。

Preventive effects of L-ascorbic acid and calcium pantothenate against photosensitive actions induced by pheophorbide alpha and hematoporphyrin.

作者信息

Kimura S, Takahashi Y

出版信息

J Nutr Sci Vitaminol (Tokyo). 1981;27(6):521-7. doi: 10.3177/jnsv.27.521.

DOI:10.3177/jnsv.27.521

Abstract

The preventive effects of L-ascorbic acid (V.C) and pantothenic acid (PaA) against photosensitized hemolysis in the presence of pheophorbide a or hematoporphyrin were investigated in vitro. The development of hematoporphyrin-induced photosensitivity and the preventive effects of V.C and PaA were also investigated in male mice. V.C and PaA exerted preventive effects against photosensitized hemolysis in the presence of pheophorbide a or hematoporphyrin. In such cases, V.C and PaA had not only an additive effect but also a synergistic one. The time required for the photosensitized acute shock-like death (i.e., survival time), was significantly extended by simultaneous administration of V.C and PaA. This supports the findings of in vitro experiments.

摘要

在体外研究了L-抗坏血酸（V.C）和泛酸（PaA）在脱镁叶绿酸a或血卟啉存在下对光致敏溶血的预防作用。还在雄性小鼠中研究了血卟啉诱导的光敏感性的发展以及V.C和PaA的预防作用。在脱镁叶绿酸a或血卟啉存在下，V.C和PaA对光致敏溶血发挥了预防作用。在这种情况下，V.C和PaA不仅具有相加作用，还具有协同作用。同时给予V.C和PaA可显著延长光致敏急性休克样死亡所需的时间（即存活时间）。这支持了体外实验的结果。