Kostas J, Hotchin J
Neurobehav Toxicol Teratol. 1981 Winter;3(4):467-9.
The effects of toluene on several behavioral measures were examined in mice exposed pre- and postnatally and continuously through behavioral testing. The test animals were the offspring of dams given solutions of toluene in drinking water (16,80 or 400 ppm) during pregnancy and lactation. After weaning, the test mice were maintained at the same toluene exposure concentrations. At 35 days of age decreased habituation of open-field activity was seen in the 400-ppm group. This effect was not found in mice which received a single intraperitoneal injection of toluene (14.4 or 72 mg/kg) in sesame seed oil. Rotorod performance, measured at 45-55 days of age, was depressed in all exposed groups. No effects of toluene exposure were seen on maternal fluid consumption, offspring mortality rate, development of eye or ear openings, or surface-righting response.
通过行为测试，研究了甲苯对产前和产后持续接触甲苯的小鼠几种行为指标的影响。实验动物是母鼠的后代，母鼠在怀孕和哺乳期饮用含甲苯溶液（16、80或400 ppm）。断奶后，实验小鼠保持在相同的甲苯暴露浓度下。在35日龄时，400 ppm组的旷场活动习惯化降低。在芝麻油中单次腹腔注射甲苯（14.4或72 mg/kg）的小鼠中未发现这种效应。在45 - 55日龄时测量的转棒试验表现，在所有暴露组中均受到抑制。未观察到甲苯暴露对母鼠液体消耗、后代死亡率、眼或耳开口发育或翻正反射有影响。
