Tamemasa O, Goto R, Takeda A
Radioisotopes. 1981 Dec;30(12):674-8.
The selective affinity of amino acids for pancreas, due to its high rate of protein synthesis, has prompted us to synthesize new radio-labeled amino acids for pancreatic imaging. Labeling of 19 unnatural amino acids with 99mTc was tried in the usual way, and 10 labeled products were obtained with low yields. The highest distribution of radioactivity from all these labeled amino acids, which had been injected intravenously into mice, was found in the kidney, whereas little activity was found in the pancreas. Thier low distributions in stomach suggest little dissociation of the labeled amino acids into 99mTcO4- in mice. It is presumed that these labeled amino acids behave unlike their original acids in the body.
由于胰腺蛋白质合成速率高，氨基酸对胰腺具有选择性亲和力，这促使我们合成新的放射性标记氨基酸用于胰腺成像。我们尝试用常规方法用99mTc标记19种非天然氨基酸，得到了10种标记产物，但产率较低。将所有这些标记氨基酸静脉注射到小鼠体内后，发现放射性分布最高的是肾脏，而胰腺中的活性很低。它们在胃中的低分布表明标记氨基酸在小鼠体内很少解离成99mTcO4-。据推测，这些标记氨基酸在体内的行为与其原始氨基酸不同。
